全文获取类型
收费全文 | 2044篇 |
免费 | 40篇 |
国内免费 | 52篇 |
专业分类
教育 | 1356篇 |
科学研究 | 260篇 |
各国文化 | 16篇 |
体育 | 299篇 |
综合类 | 178篇 |
信息传播 | 27篇 |
出版年
2024年 | 1篇 |
2023年 | 2篇 |
2022年 | 15篇 |
2021年 | 37篇 |
2020年 | 37篇 |
2019年 | 54篇 |
2018年 | 61篇 |
2017年 | 54篇 |
2016年 | 54篇 |
2015年 | 67篇 |
2014年 | 112篇 |
2013年 | 207篇 |
2012年 | 148篇 |
2011年 | 146篇 |
2010年 | 110篇 |
2009年 | 100篇 |
2008年 | 113篇 |
2007年 | 144篇 |
2006年 | 124篇 |
2005年 | 121篇 |
2004年 | 86篇 |
2003年 | 78篇 |
2002年 | 70篇 |
2001年 | 47篇 |
2000年 | 51篇 |
1999年 | 21篇 |
1998年 | 10篇 |
1997年 | 16篇 |
1996年 | 13篇 |
1995年 | 9篇 |
1994年 | 5篇 |
1993年 | 7篇 |
1992年 | 7篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
排序方式: 共有2136条查询结果,搜索用时 250 毫秒
11.
不同品种黄瓜幼苗光合机构对盐胁迫的响应 总被引:26,自引:0,他引:26
研究了盐胁迫(0、25、50mmol/L)对不同品种黄瓜幼苗生长、光合作用和叶绿素荧光的影响.结果表明,盐胁迫,尤其是高浓度NaCl(50mmol/L)的胁迫,显著降低黄瓜幼苗生长量、叶绿素含量、光系统Ⅱ光合电子传递量子效率(φPSⅡ)、净光合速率(Pn)、气孔导度(Gs)以及气孔限制值(Ls),同时显著提高叶片相对电导率、丙二醛、脯氨酸含量和细胞间CO2浓度(Ci),光系统Ⅱ的光化学效率(Fv/Fm)变化不大.盐胁迫对耐盐黄瓜‘津研4号’幼苗生长的影响小于盐敏感黄瓜‘津绿4号’,这可能与耐盐黄瓜在盐胁迫下较高的净光合速率、光系统Ⅱ光合电子传递量子效率和较低的丙二醛(MDA)含量、相对电导率有关。 相似文献
12.
文章在阐述组织承诺与压力管理的概念解析和关系认识基础上,同时基于对组织承诺与压力管理的问题进行诊断,从组织层面提出了两者的关系优化路径。 相似文献
13.
Singh PP Chandra A Mahdi F Roy A Sharma P 《Indian journal of clinical biochemistry : IJCB》2010,25(3):225-243
The antioxidants are essential molecules in human system but are not miracle molecules. They are neither performance enhancers
nor can prevent or cure diseases when taken in excess. Their supplemental value is debateable. In fact, many high quality
clinical trials on antioxidant supplement have shown no effect or adverse outcomes ranging from morbidity to all cause mortality.
Several Chochrane Meta-analysis and Markov Model techniques, which are presently best available statistical models to derive
conclusive answers for comparing large number of trials, support these claims. Nevertheless none of these statistical techniques
are flawless. Hence, more efforts are needed to develop perfect statistical model to analyze the pooled data and further double
blind, placebo controlled interventional clinical trials, which are gold standard, should be implicitly conducted to get explicit
answers. Superoxide dismutase (SOD), glutathione peroxidase and catalase are termed as primary antioxidants as these scavenge
superoxide anion and hydrogen peroxide. All these three enzymes are inducible enzymes, thereby inherently meaning that body
increases or decreases their activity as per requirement. Hence there is no need to attempt to manipulate their activity nor
have such efforts been clinically useful. SOD administration has been tried in some conditions especially in cancer and myocardial
infarction but has largely failed, probably because SOD is a large molecule and can not cross cell membrane. The dietary antioxidants,
including nutrient antioxidants are chain breaking antioxidants and in tandem with enzyme antioxidants temper the reactive
oxygen species (ROS) and reactive nitrogen species (RNS) within physiological limits. Since body is able to regulate its own
requirements of enzyme antioxidants, the diet must provide adequate quantity of non-enzymic antioxidants to meet the normal
requirements and provide protection in exigent condition. So far, there is no evidence that human tissues ever experience
the torrent of reactive species and that in chronic conditions with mildly enhanced generation of reactive species, the body
can meet them squarely if antioxidants defense system in tissues is biochemically optimized. We are not yet certain about
optimal levels of antioxidants in tissues. Two ways have been used to assess them: first by dietary intake and second by measuring
plasma levels. Lately determination of plasma/serum level of antioxidants is considered better index for diagnostic and prognostic
purposes. The recommended levels for vitamin A, E and C and beta carotene are 2.2–2.8 μmol/l; 27.5–30 μmol/l; 40–50 μmol/l
and 0.4–0.5 μmol/l, respectively. The requirement and recommended blood levels of other dietary antioxidants are not established.
The resolved issues are (1) essential to scavenge excess of radical species (2) participants in redox homeostasis (3) selective
antioxidants activity against radical species (4) there is no universal antioxidant and 5) therapeutic value in case of deficiency.
The overarching issues are (1) therapeutic value as adjuvant therapy in management of diseases (2) supplemental value in developing
population (3) selective interactivity of antioxidant in different tissues and on different substrates (4) quantitative contribution
in redox balance (5) mechanisms of adverse action on excess supplementation (6) advantages and disadvantages of prooxidant
behavior of antioxidants (7) behavior in cohorts with polymorphic differences (8) interaction and intervention in radiotherapy,
diabetes and diabetic complications and cardiovascular diseases (9) preventive behavior in neurological disorders (10) benefits
of non-nutrient dietary antioxidants (11) markers to assess optimized antioxidants status (12) assessment of benefits of supplementation
in alcoholics and heavy smokers. The unresolved and intriguing issues are (1) many compounds such as vitamin A and many others
possessing both antioxidant and non-antioxidant properties contribute to both the activities in vivo or exclusively only to
non-antioxidant activity and (2) since human tissues do not experience the surge of FR, whether there is any need to develop
stronger synthetic antioxidants. Theoretically such antioxidants may do more harm than good. 相似文献
14.
我国高校教师压力随着经济实力的增长,和教学改革的推进而不断增大,原因来自于社会、学校和自身各方面,本文主要通过与瑞典高校教师的压力的比较,吸取国外优秀的经验,解决我国对前存在的教师压力问题。 相似文献
15.
16.
Munzir M. E. Ahmed J. A. S. Al-Obosi H. M. Osman M. E. Shayoub 《Indian journal of clinical biochemistry : IJCB》2016,31(2):162-170
Acetaminophen (APAP) a commonly used drug for decrease the fever and pain but is capable to induced hepatotoxicity at over dose. This study was carried out to investigate the effect of APAP on the expression of anti-apoptotic and antioxidative defense genes, and whether aldose reductase over-expressing plasmid capable to protect against APAP-induced oxidative stress and cell death. APAP treatment induced oxidative stress and hepatotoxicity, and significantly increased aldose reductase mRNA and protein expression in mouse hepatocyte (AML-12). Unexpectedly, AML-12 cells over-expressing aldose reductase augmented APAP-induced reduction in cell viability, reactive oxygen species (ROS) production, glutathione (GSH) depletion and glutathione S-transferase A2 expression. Moreover, over-expression of aldose reductase potentiated APAP induced reduction on proliferating cell nuclear antigen, B cell lymphoma-extra large (bcl-xL), catalase, glutathione peroxidase-1 (GPx-1) and abolished APAP-induced B-cell lymphoma 2 (bcl-2) inductions. Further, over-expression of aldose reductase significantly abolished AMP activated protein kinase (AMPK) activity in APAP-treated cells and induced p53 expression. This results demonstrate that APAP induced toxicity in AML-12, increased aldose reductase expression, and over-expression of aldose reductase render this cell more susceptible to APAP induced oxidative stress and cell death, this probably due to inhibition AMPK or bcl-2 activity, or may due to competition between aldose reductase and glutathione reductase for NADPH. 相似文献
17.
水分胁迫对黄淮海夏玉米农业气候资源利用的影响——水分胁迫对叶片生产力影响 总被引:2,自引:0,他引:2
文章对水分胁迫的夏玉米光合生产力变化进行了系统观测和实验 ,研究表明 :①可将土壤持水量的 4 0 6 89%~ 5 5 79%和 79 99%作为叶片缺水及最适的外部形态指标 ;②干旱可以使株高低 2 2 5 6 %左右 ,而短时间内水分一直维持在田间持水量水平 ,对玉米的株高影响并不大 ;③比叶重随土壤湿度增加而增大 ,到田间持水量的 79 9%时达到最大值 ,随着湿度的进一步增加 ,比叶重反而略微变小 ;④叶片含水量与土壤湿度成正相关 ,吸收辐射率则受叶片湿度与厚度的影响 ,当土壤湿度达到持水量的 79 99%时 ,叶片吸收辐射率可达到 80 %左右。在此研究基础上 ,给出了包含浓度、辐射强度、温度及土壤水分因子的夏玉米叶片生产力计算公式 ,为进一步准确推算水分胁迫对区域生产力的可能影响 ,为当地政府开发农业气候资源提供了前提条件。 相似文献
18.
M. Maneesh Sanjiba Dutta Amit Chakrabarti D M Vasudevan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):138-142
Infertility is well-established harmful effect in chronic alcoholism and so far, there is no effective treatment for this
condition. The study was conducted to determine the effects of alpha tocopherol on ethanol induced testicular injuries in
male albino rats of Wistar strain. Five groups (n=6) of animals were used. Group I served as control. Group II received daily
1.6g ethanol/kg body weight/day for 4 weeks orally. Group III received 1.6g ethanol+80mg alpha tocopherol/kg body weight/day
for four weeks orally. Group IV received 1.6g ethanol/kg body weight for/day 4 weeks and followed by 80mg alpha tocopherol/kg
body weight/day for four weeks orally. Group V received 1.6g ethanol/kg body weight/day orally for 4 weeks, followed by 4
weeks abstinence. Twently-four hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were
removed and used for the estimation of extent of lipid peroxidation and tissue levels of antioxidants and steroidogenic enzymes.
Alpha tocopherol treatment increased the activities of testicularΔ
5, 3β-HSD. Moreover, the treatment was also associated with significant decrease in testicular oxidative stress. Ethanol-induced
oxidative stress and decreased steroidogenesis can be reversed by treatment with alpha tocopherol. 相似文献
19.
给出新型三类用理性杂交模式、根据一种修正的Hellinger-Reissner原理、建立高精度非协调轴对称实体旋转有限元时,其单元刚度矩阵的准确计算式。 相似文献
20.
The authors explored the relationship between counseling trainees' emotional intelligence (EI), empathy, stress, distress, and demographics. Results indicated that higher levels of EI were associated with lower stress and distress, higher affective and cognitive empathy, and age. These findings suggest curricular integration of EI and potential utility of EI measures to evaluate students' progress throughout the program. 相似文献